Comparison of two inverse planning algorithms for cervical cancer brachytherapy

PURPOSE To compare two inverse planning algorithms, the hybrid optimization (HIPO) algorithm and simulated annealing (IPSA) algorithm, for cervical cancer brachytherapy provide suggestions their usage. MATERIAL AND METHODS This study consisted of 24 patients treated with CT image-based high-dose-rate using various combinations tandem/ovoid applicator interstitial needles. For fixed catheter configurations, plans were retrospectively optimized methods: IPSA HIPO. The dosimetric parameters respect to target coverage, localization high dose volume (LHDV), conformal index (COIN), sparing organs at risk (OARs) evaluated. A plan assessment method which combines a graphical analysis scoring was used quality each case. characteristics dwell time distributions also analyzed in detail. RESULTS Both HIPO can produce clinically acceptable treatment plans. rectum D2cc slightly lower as compared (P = 0.002). All other targets OARs not significantly different between algorithms. generated radar plots scores intuitively presented properties enabled reflect clinical priorities Significant observed by CONCLUSIONS algorithms could generate high-quality plans, but performances terms specific patient. decision on optimal patient be made quickly consistently help method. Besides, distribution suggested taken into account during selection. Compared IPSA, may closer preference.